Recombinant Human GLUD1 Protein

重组人GLUD1蛋白 | 重组人谷氨酸脱氢酶1蛋白

I118167 | DHE3_HUMAN | EC 1.4.1.3 | GDH | GDH 1 | Gdh-X | GDH1 | GLUD | Glud1 | Glud1a | Glud1b | Gludl | Glutamate dehydrogenase (NAD(P)+) | Glutamate dehydrogenase 1 | Glutamate dehydrogenase 1 mitochondrial | Glutamate dehydrogenase 1a | Glutamate dehy

rp188499-10μg

10μg

无载体

≥80%(SDS-PAGE)

Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:11254391, PubMed:16023112, PubMed:16959573). Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). Post-translational: ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (PubMed:16959573). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer (PubMed:16023112).

重组表达

56.9 kDa

N-His

52.4 kDa, under reducing conditions.

E. coli Accession #: P00367 | E. coli

<1.0 EU/μg

人(Human)

54-558 aa

MHHHHHHSEAVADREDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT​

No

Yes