Recombinant Human NUDT21/CFIM25 Protein

重组人NUDT21/CFIM25蛋白 | 重组人Nudix水解酶21蛋白

CFIM 25 | CFIM25 | Cleavage and polyadenylation specific factor 5 | Cleavage and polyadenylation specific factor 5 25 kD subunit | Cleavage and polyadenylation specific factor 5 25 kDa | Cleavage and polyadenylation specificity factor 25 kDa subunit | Cle

rp188503-10μg

10μg

无载体

≥95%(SDS-PAGE)

Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export. Post-translational: Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 and SIRT2.

重组表达

27.0 kDa

N-His

26.5 kDa, under reducing conditions; 26.5 kDa, under non-reducing conditions.

E. coli Accession #: O43809 | E. coli

<1.0 EU/μg

人(Human)

2-227 aa

MHHHHHHSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN​

No

Yes