Recombinant Human YOD1 Protein

重组人YOD1蛋白 | 重组人去泛素化酶蛋白

DUBA-8 | DUBA8 | HIN-7 | HIV-1-induced protease 7 | HsHIN7 | OTU domain containing 2 | OTU domain-containing protein 2 | OTU1_HUMAN | OTUD2 | PRO0907 | RP11-164O23.1 | Ubiquitin thioesterase OTU1 | yod1 | YOD1 OTU deubiquinating enzyme 1 homolog (S. cerev

rp188513-10μg

10μg

无载体

≥95%(SDS-PAGE)

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

重组表达

39.1 kDa

N-His

42.1 kDa, under reducing conditions; 42.2 kDa, under non-reducing conditions.

E. coli Accession #: Q5VVQ6 | E. coli

<1.0 EU/μg

人(Human)

2-348 aa

MHHHHHHFGPAKGRHFGVHPAPGFPGGVSQQAAGTKAGPAGAWPVGSRTDTMWRLRCKAKDGTHVLQGLSSRTRVRELQGQIAAITGIAPGGQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIIEEDQTRPRSSPAFTKRGASSYVRETLPVLTRTVVPADNSCLFTSVYYVVEGGVLNPACAPEMRRLIAQIVASDPDFYSEAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTPPLTIFSSNDDIVLVQALELADEARRRRQFTDVNRFTLRCMVCQKGLTGQAEAREHAKETGHTNFGEV​

No

Yes