Recombinant Human CDK2AP1 Protein

重组人CDK2AP蛋白 | 重组人细胞周期素依赖性激酶2关联蛋白1

CDK2-associated protein 1 | cyclin-dependent kinase 2-associated protein 1 | CDKAP1 | cyclin-dependent kinase 2 associated protein 1 | Deleted in oral cancer 1 | Deleted in oral cancer-1 | DOC-1 | DOC1 | Putative oral cancer suppressor | DORC1 | p12DOC-1

rp189302-10μg

10μg

无载体

≥95%(SDS-PAGE)

CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Also, interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. Post-translational: Phosphorylated in vitro by IKBKE at Ser-46.

重组表达

13.2 kDa

N-His

13.0 kDa, under reducing conditions; 13.0 kDa, under non-reducing conditions.

E. coli Accession #: O14519 | E. coli

<1.0 EU/μg

人(Human)

2-115 aa

MHHHHHHSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS

No

Yes