Recombinant Human Endothelin-2/ET-2 Protein

重组人Endothelin-2蛋白 | 重组人ET-2蛋白 | 重组人内皮素-2蛋白

EDN2 | EDN2_HUMAN | Endothelin 2 | Endothelin-2 | ET 2 | ET-2 | ET2 | PPET2 | Preproendothelin 2 | Preproendothelin-2

rp192066-10μg

10μg

无载体

≥90%(SDS-PAGE)

Endothelin-2 is a Hypoxia-induced Autocrine Survival Factor for Breast Tumor Cells. The synthesis of EDN2 by human kidney carcinoma cells is decreased by EGF. EDN2 is a chemoattractant for macrophages and THP-1 monocytic cells. Chemotaxis towards EDN2 is via the MAPK pathway: p44 and p42 are phosphorylated when THP-1 cells are stimulated with EDN2. Migration to EDN2 is inhibited by hypoxia and by pertussis toxin. EDN2 leads to activation of macrophages. EDN2 shares a similar peptide sequence with chemokines and may signal via a similar receptor and MAPK-mediated pathway. Furthermore, EDN2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.

重组表达

18.4 kDa

N-His

18.3 & 35.7 kDa, under reducing conditions; 21.3 & 35.3 & 51.6 kDa, under non-reducing conditions.

E. coli Accession #: P20800 | E. coli

<1.0 EU/μg

人(Human)

25-178 aa

MHHHHHHQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGAVPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR

No

Yes