Recombinant Human EIF3I Protein

重组人EIF3I蛋白 | 重组人真核翻译起始因子3I蛋白

eIF-3-beta | eIF3 beta | eIF3 p36 | eIF3-beta | eIF3-p36 | eIF3i | EIF3I_HUMAN | EIF3S2 | Eukaryotic translation initiation factor 3 subunit 2 | Eukaryotic translation initiation factor 3 subunit 2 beta | Eukaryotic translation initiation factor 3 subunit

rp192075-10μg

10μg

无载体

≥90%(SDS-PAGE)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Post-translational: Phosphorylated by TGF-beta type II receptor.

重组表达

37.3 kDa

N-His

35.4 kDa, under reducing conditions.

E. coli Accession #: Q13347 | E. coli

<1.0 EU/μg

人(Human)

2-325 aa

MHHHHHHKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA​

No

Yes