Recombinant Human Bcl-XL Protein

重组人Bcl-XL蛋白 | 重组人B细胞淋巴瘤因子2 XL蛋白

poptosis regulator Bcl X | Apoptosis regulator Bcl-X | Apoptosis regulator BclX | B cell lymphoma 2 like | B2CL1_HUMAN | Bcl 2 like 1 protein | Bcl X | Bcl xL | BCL XL/S | Bcl xS | Bcl-2-like protein 1 | Bcl2 Like 1 | Bcl2 related gene | Bcl2-L-1 | BCL2L

rp209934-10μg

10μg

无载体

≥95%(SDS-PAGE)

Bcl-X, also named as BCL2L1 or BCL2L, belongs to the Bcl-2 family and it is encoded by the BCL2L1 gene in human. Alternative splicing of Bcl-X results in at least two isoforms，isoform Bcl-X(L) (also named as Bcl-xL) and isoform Bcl-x(S) (also named as Bcl-xS). Bcl-xL is found in tissues containing long-lived postmitotic cells, such as adult brain, while Bcl-xS is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. Bcl-X forms homodimer or heterodimer with other Bcl-2 proteins, like BAK, BAX or Bcl-2, to act as anti- or pro- apoptotic regulators. Bcl-xL appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane, and it also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. In contrast, Bcl-xS is a pro-apoptotic protein that promotes apoptosis. Post-translational: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity. Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome.

Immobilized Recombinant Human BID Protein (rp183602) at 2.0 μg/mL can bind Recombinant Human Bcl-XL Protein (rp209934) with the EC50 of 261.4 ng/mL.

重组表达

24.8 kDa

C-His

27.6 kDa, under reducing conditions; 27.6 & 53.2 kDa, under non-reducing conditions.

E. coli Accession #: Q07817 | E. coli

人(Human)

1-212 aa (G70A)

MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRLEHHHHHH

No

Yes