Recombinant Human FTO Protein

重组人FTO蛋白 | 重组人α-酮戊二酸依赖性双加氧酶FTO蛋白

AlkB homolog 9 | ALKBH9 | Alpha-ketoglutarate-dependent dioxygenase FTO | AW743446 | Fat mass and obesity-associated protein | FATSO, MOUSE, HOMOLOG OF | Fto | FTO_HUMAN | GDFD | KIAA1752 | mKIAA1752 | Protein fatso

rp214414-10μg

10μg

无载体

≥80%(SDS-PAGE)

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.

重组表达

59.1 kDa

N-His

57.1 kDa, under reducing conditions; 57.1 kDa, under non-reducing conditions.

E. coli Accession #: Q9C0B1 | E. coli

<1.0 EU/μg

人(Human)

2-505 aa

MHHHHHHKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP

No

Yes