Recombinant Human p63 Protein

重组人p63蛋白 | 重组人肿瘤蛋白63

AIS | Amplified in squamous cell carcinoma | B(p51A) | B(p51B) | Chronic ulcerative stomatitis protein | CUSP | DN p63 alpha 1 | DNp63 | EEC3 | id:ibd3516 | Keratinocyte transcription factor | Keratinocyte transcription factor KET | KET | LMS | MGC115972

rp214418-10μg

10μg

无载体

≥90%(SDS-PAGE)

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Post-translational: May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

重组表达

35.0 kDa

N-His

31.8 kDa, under reducing conditions; 31.1 & 76.2 & 131.9 kDa, under non-reducing conditions.

E. coli Accession #: Q9H3D4 | E. coli

<1.0 EU/μg

人(Human)

381-680 aa

MHHHHHHNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDARRNKQQRIKEEGE

No

Yes