Recombinant Human LAMP-1/CD107a Protein

重组人 LAMP-1/CD107a 蛋白 | 重组人溶酶体相关膜蛋白1

CD107 antigen-like family member A | CD107a antigen | CD107a | LAMP1 | LAMP-1 | LAMPA | LGP120 | lysosomal-associated membrane protein 1 | lysosome-associated membrane glycoprotein 1 | Lysosome-associated membrane protein 1

rp214422-10μg

10μg

无动物源

≥95%(SDS-PAGE)

Lysosomal associated membrane protein 1 (LAMP1), also known as CD107a and LGP120, is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature human LAMP1 consists of a 354 amino acid (aa) intralumenal domain (ECD), a 23 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, human LAMP1 shares approximately 64% aa sequence identity with mouse and rat LAMP1. The sorting of LAMP1 to lysosomes relies on a tyrosine motif in the cytoplasmic tail. In cytotoxic T cells and mast cells, LAMP1 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin, granzymes, eicosanoids, and histamine. LAMP1 is presented on the plasma membrane during the activation of NK cells, CD8+ T cells, mast cells, basophils, monocytes, and platelets. A glycoform of LAMP1 known as M150 is expressed on the surface of activated macrophages, where it promotes T cell costimulation and a Th1-biased immune response. Exposure of epithelial cells to pathogenic Neisseria bacteria induces the redistribution of LAMP1 to the cell surface, where it can be cleaved by the Neisseria IgA1 protease. LAMP1 is a native ligand for the lectins Galectin-1 and Galectin-3. Post-translational: O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.(Microbial infection) The glycosylation of Asn-76 is essential for Lassa virus entry into cells.

Immobilized Recombinant Human Galectin-3 Protein (rp179829) at 5.0 μg/mL can bind Recombinant Human LAMP-1/CD107a Protein (rp214422) with the EC50 of 3.5 μg/mL.

重组表达

39.2 kDa

C-His

51.6-86.5 kDa, under reducing conditions; 51.6-86.5 kDa, under non-reducing conditions.

HEK293 Accession #: P11279 | HEK293

<1.0 EU/μg

人(Human)

1-382 aa

MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMHHHHHH

Yes

Yes