Recombinant Human Thymidylate Synthase Protein

dTMP synthase | EC 2.1.1.45 | HsT422 | MGC88736 | OTTHUMP00000162195 | Thymidylate synthase | Thymidylate synthetase | TMS | TS | TSase | Tyms | TYMS protein | Tyms thymidylate synthetase | TYSY_HUMAN

rp214458-10μg

10μg

无载体

≥90%(SDS-PAGE)

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor which maintains the dTMP (thymidine-5-prime monophosphate) pool vital for DNA replication and repair. Thymidylate synthase plays an important role as a cancer chemotherapeutic agent. Thymidylate synthase is the primary site of action for 5-fluoro-2-prime-deoxyuridine and several folate analogs.

重组表达

36.5 kDa

N-His

32.5 kDa, under reducing conditions; 32.5 kDa, under non-reducing conditions.

E. coli Accession #: P04818 | E. coli

人(Human)

2-313 aa

MHHHHHHPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV

No

Yes