Recombinant Human SNF5/SMARCB1 Protein

重组人SNF5蛋白

BAF47 | BRG1-associated factor 47 | hSNF5 | INI1 | Integrase interactor 1 protein | Malignant rhabdoid tumor suppressor | RDT | RTPS1 | Sfh1p | SMARCB1 | SNF5 homolog | SNF5_HUMAN | SNF5L1 | Snr1 | Sucrose nonfermenting yeast homolog like 1 | SWI/SNF comp

rp214469-10μg

10μg

无载体

≥95%(SDS-PAGE)

Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.

重组表达

12.3 kDa

N-His

15.2 kDa, under reducing conditions; 15.3 kDa, under non-reducing conditions.

E. coli Accession #: Q12824 | E. coli

<1.0 EU/μg

人(Human)

81-181 aa

MHHHHHHYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENAS

No

Yes