Recombinant Human Betacellulin Protein

重组人Betacellulin蛋白 | 重组人β细胞素蛋

Betacellulin | Betacellulin precursor | BTC | BTC_HUMAN | OTTHUMP00000160600 | OTTHUMP00000219057 | Probetacellulin

rp215067-10μg

10μg

无载体

≥95%(SDS-PAGE)

Betacellulin(BTC) is a member of the epidermal growth factor (EGF) family. These soluble proteins are ligands for one or more of the four receptor tyrosine kinases encoded by the ErbB gene family (ErbB-1/epidermal growth factor receptor (EGFR), neu/ErbB-2/HER2, ErbB-3/HER3 and ErbB-4/HER4). Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. This protein is a ligand for the EGF receptor. BTC is a polymer of about 62-111 amino acid residues. Secondary Structure: 6% helical (1 helices; 3 residues)36% beta sheet (5 strands; 18 residues). BTC was originally identified as a growth-promoting factor in mouse pancreatic β-cell carcinoma cell line and has since been identified in humans. It plays a role in the growth and development of the neonate and/or mammary gland function. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 1.19 ng/mL.

重组表达

9.8 kDa

No tag

15.2 kDa, under reducing conditions; 15.5 kDa, under non-reducing conditions

E. coli Accession #: P35070.1 | E. coli

<1.0 EU/μg

人(Human)

32-118 aa

GDGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQ

No

Yes