Recombinant Human PRNP/Prion Protein

重组人PRNP/Prion蛋白 | 重组人朊蛋白

Alternative prion protein | major prion protein | AltPrP | ASCR | CD230 | CD230 antigen | CJD | GSS | KURU | p27 30 | PRIO_HUMAN | Prion protein | Prion related protein | PRIP | PRNP | PrP | PrP27 30 | PrP27-30 | PrP33-35C | PrPC | PrPSc | Sinc

rp217133-10μg

10μg

无载体

≥90%(SDS-PAGE)

he function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis (By similarity). Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Post-translational: The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.

重组表达

23.7 kDa

N-His

25.7 kDa, under reducing conditions

E. coli Accession #: P04156 | E. coli

<1.0 EU/μg

人(Human)

23-230 aa

MHHHHHHKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGS

No

Yes