Recombinant Human MCM7 Protein

重组人MCM7蛋白 | 重组人微型染色体维护复杂组件7蛋白

CDABP0042 | CDC 47 | CDC47 | CDC47 homolog | Cdc47, S. cerevisiae, homolog of | DNA replication licensing factor MCM7 | Homolog of S. cerevisiae Cdc47 | MCM 2 | MCM 7 | MCM2 | MCM2, formerly | Mcm7 | MCM7 minichromosome maintenance deficient 7 | MCM7_HUMA

rp217597-10μg

10μg

无载体

≥90%(SDS-PAGE)

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Post-translational: Phosphorylated upon DNA damage, probably by ATM or ATR.

重组表达

16.8 kDa

N-His

17.0 & 34.9 kDa, under reducing conditions; 17.0 & 34.9 kDa, under non-reducing conditions.

E. coli Accession #: P33993 | E. coli

<1.0 EU/μg

人(Human)

188-328 aa

MHHHHHHGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIA​

No

Yes