Recombinant Human DNMT3A Protein

重组人DNMT3A蛋白 | 重组人DNA甲基转移酶3 α蛋白

DNA (cytosine 5) methyltransferase 3 alpha | DNA (cytosine 5) methyltransferase 3A | DNA (cytosine-5)-methyltransferase 3A | DNA cytosine methyltransferase 3A2 | DNA methyltransferase 3 alpha | DNA methyltransferase 3a | DNA methyltransferase HsaIIIA | DN

rp218433-10μg

10μg

无载体

≥95%(SDS-PAGE)

Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. Post-translational: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription. Auto-methylated at Cys-710: auto-methylation takes place in absence of DNA substrate and inactivates the DNA methyltransferase activity. Inactivation by auto-methylation may be used to inactivate unused DNA methyltransferases in the cell.

重组表达

16.2 kDa

N-His

20.2 kDa, under reducing conditions; 20.3 & 43.5 kDa, under non-reducing conditions.

E. coli Accession #: Q9Y6K1 | E. coli

<1.0 EU/μg

人(Human)

353-486 aa

MHHHHHHAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQK

No

Yes