Recombinant Human ATG7 Protein

重组人ATG7蛋白 | 重组人自噬相关蛋白7

APG7 autophagy 7-like (S. cerevisiae) | APG7 | APG7L | APG7-LIKE | ATG12-activating enzyme E1 ATG7 | ATG7 autophagy related 7 homolog (S. cerevisiae) | ATG7 | Autophagy-related protein 7 | DKFZp434N0735 | GSA7 | hAGP7 | ubiquitin activating enzyme E1-like

rp218434-10μg

10μg

无载体

≥90%(SDS-PAGE)

ATG7, also known as APG7, is a 78 kDa cytosolic ubiquitin-E1-like enzyme that plays a key role in the autophagic pathway of intracellular bulk degradation. It is required for the conjugation of ATG5 to ATG12, the lipidation of ATG8, and subsequent autophagosome formation. ATG7 is required for mitochondrial removal during erythropoiesis and for the maintenance of axonal homeostasis. Alternate splicing of human ATG7 generates an isoform that lacks 31 aa at the C-terminus, a region that is required for ATG8 lipidation. Human ATG7 shares 93% aa sequence identitiy with mouse and rat ATG7. Post-translational: Acetylated by EP300.Polyubiquitinated on Lys-45 via 'Lys-63'-linked ubiquitin by TRIM32; this modification positiely regulates ATG8 and ATG12 activating enzyme activity leading to initiation of autophagy under metabolic stress.

重组表达

21.1 kDa

N-His

21.5 kDa, under reducing conditions; 20.6 & 41.7 & 61.2 kDa, under non-reducing conditions.

E. coli Accession #: O95352 | E. coli

<1.0 EU/μg

人(Human)

387-570 aa

MHHHHHHNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQ

No

Yes