Recombinant Human HDAC4 Protein

重组人HDAC4蛋白 | 重组人组蛋白去乙酰化酶4

AHO3 | BDMR | EC 3.5.1.98 | HA6116 | HD 4 | HD4 | HDAC 4 | HDAC A | HDAC4 | HDAC4_HUMAN | HDACA | Histone deacetylase 4 | Histone Deacetylase A | KIAA0288

rp218436-10μg

10μg

无载体

≥85%(SDS-PAGE)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Post-translational: Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350, within the PxLPxI/L motif, impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3.Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.

重组表达

15.8 kDa

No tag

19.8 kDa, under reducing conditions; 19.8 kDa, under non-reducing conditions.

E. coli Accession #: P56524 | E. coli

<1.0 EU/μg

人(Human)

456-592 aa

GLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLF

No

Yes