Colipase

rp221826-1mg

1mg

生物活性

≥4000 U/mg powder

在处于或高于胆酸盐临界胶束温度时，所制备的几乎不 含共脂肪酶的胰脂肪酶在与胆酸盐结合后会被强烈抑制。 共脂肪酶的加入恢复了受胆酸盐抑制的脂肪酶的活性， 凝胶过滤实验表明，在胆盐溶液中，共脂肪酶与脂肪酶形 成 1:1 复合物的二聚体。 【产品特性】 脂肪酶和共脂肪酶以化学计量关系相互作用，并将共脂肪酶相互作用（所产生的酶）归类为脂肪酶的辅酶。共脂肪酶是一种分子量约 11000 的单链多肽，具有 5 个二硫键、等电点 5.0 。 【用途和作用】 在诊断试验中使用共脂肪酶作为共乳化剂，结合生色脂肪酶底物测定脂肪酶活性。 【注意事项】 为了您的安全和健康，请穿实验服并戴一次性手套操作。 Pancreatic lipase when prepared essentially free of colipase is strongly inhibited by conjugated bile salts at or above their critical micell concentration. Addition of colipase restores activity to the bile-salt-inhibited lipase and gel filtration experiments indicate that colipase in bile salt solution makes a dimer which forms a 1:1 complex with lipase. 【Properties】 Lipase and colipase interact as a stoichiometrical relationship and classified colipase interact as a co-enzyme for lipase. The colipase is a single chain polypeptide with a molecular weight approximately 11,000 with 5 disulfide bridges and isoelectric point 5.0. 【Application】 Use Colipase as a co-emulslfier in diagnostic tests for the determination of lipase activity in combination with chromogenic Lipase Substrate. 【Attention】 For your safety and health, please wear Lab coat and disposable gloves.

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.

效价：≥4000 单位/毫克粉末。比活力：≥4210 单位/毫克蛋白。单位定义 1U:在 25℃下，三丁酸甘油酯每分钟释放一微摩尔的脂肪酸。

天然

11 kDa

NONH for all modes of transport

猪(Porcine)