Recombinant Human CCNB1 Protein

重组人CCNB1蛋白 | 重组人G2/M期特异性细胞周期蛋白 B1

CCNB | CCNB 1 | ccnb1 | CCNB1_HUMAN | Cyclin B1 | G2 mitotic specific cyclin B1 | G2/mitotic-specific cyclin-B1

rp223892-10μg

10μg

无载体

≥90%(SDS-PAGE)

Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis. CCNB1 creates a complex with p34(cdc2) to form the maturation-promoting factor (MPF). CCNB1 is vital for the control of the cell cycle at the G2/M (mitosis) transition. CCNB1 builds up steadily during the G2 and is immediately destroyed at mitosis. The 2 alternative transcripts produce a constitutively expressed transcript and a cell cycle-regulated transcript which is expressed predominantly during G2/M phase. These transcripts are a result of alternate transcription initiation sites. Post-translational: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811). Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.

重组表达

10.6 kDa

N-His

12.2 kDa, under reducing conditions; 12.2 kDa, under non-reducing conditions.

E. coli Accession #: P14635 | E. coli

<1.0 EU/μg

人(Human)

2-91 aa

MHHHHHHALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVP

No

Yes