重组耐碱蛋白A

Recombinant Protein A | Protein A | Staphylococcal Protein A | Staphylococcal Protein A Recombinant | Immunoglobulin G-binding protein A | gG-binding protein A | Immunoglobulin G binding protein A | SPA | rat-PA

rp224197-10mg

10mg

无动物源

≥90%(SDS-PAGE)

本公司生产的耐碱重组蛋白A由原核系统表达、经分离纯化等步骤制成，分子量约为29 kDa。本蛋白产品N-末端带有His6标签序列。 The alkali resistant recombinant protein A produced by our company is expressed in a prokaryotic system, separated and purified, and has a molecular weight of approximately 29 kDa. This protein product has a His6 tag sequence at the N-terminus.

Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity).

重组表达

29 kDa

N-His

29 kDa

E. coli Accession #: P02976 | E. coli

金黄色葡萄球菌(Staphylococcus aureus)

Yes

Yes