Irinotecan是一种Topoisomerase I抑制剂，作用于LoVo细胞和HT-29细胞，IC50分别为15.8 μM和5.17 μM。 Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. Irinotecan hydrochloride has been used: in combination with 5-fluorouracil for screening growth inhibitory functionality in MDA-MB-231 breast cancer cells. in chemosensitivity screening of high-grade appendiceal (HGA) and low-grade appendiceal (LGA) organoids. as a chemotherapeutic agent in the cytotoxicity studies in combination with heat shock proteins inhibitors (HPSC1) in HT29 colon cancer cells.