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中文名称
3-吡啶甲腈
英文名称
pyridine-3-carbonitrile
中文别名
3-吡啶甲腈 | 烟酸腈
英文别名
3-Pyridyl cyanide | NCGC00248004-02 | NSC17558 | NSC-17558 | 3-Pyridinecarboxylic acid, nitrile | CHEBI:86556 | EC 202-863-0 | SB52234 | 3-cyanopyridine | 3-Pyridinecarbonitrile, 98% | Nicotinonitrile | AC-2424 | AM81277 | BRN 0107711 | DTXSID1026665 | In
CAS号
100-54-9
分子式
C6H4N2
分子量
104.11
精确质量
≥98%(GC)
PSA
36.7
Logp
0.2
危险属性
- 危害摘要： 皮肤、眼睛和粘膜刺激物；紧急治疗：吡啶；吡啶是一种刺激性物质，摄入半杯或吸入 6-12 ppm 后会引起中枢神经系统抑制；可引起肝损伤和肾损伤；在致死剂量研究的大鼠中引起呼吸抑制和肝脏变化；[RTECS] 一种刺激物；误食有害；[Alfa Aesar MSDS] 参见 m-邻苯二甲二腈。
- 处置方法： SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
- 有害效应： 职业性肝毒素 - 继发性肝毒素：环境中的毒性效应潜力基于人摄入中毒或动物实验的案例。
- 法规信息： 新西兰 EPA 化学品状态清单：3-吡啶腈：没有单独的批准，但可以在适当的群体标准下使用。
- 环境归宿： 大气命运：根据半挥发性有机化合物在大气中的气/粒子分配模型 (1)，3-吡啶腈，其在 25 °C(2) 时的蒸气压为 0.296 mm Hg，预计仅以蒸气形式存在于环境大气中 (SRC)。气相态的 3-吡啶腈在大气中被光化学产生的羟基自由基降解 (SRC)；该反应在空气中的半衰期估计为 246 天 (SRC)，根据其速率常数计算得出，该速率常数为 6.53X10^-14 cu cm/molecule-sec at 25 °C(SRC)，使用结构估算方法确定 (3)。
- 预防措施： SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
- 人为污染源： 3-Pyridinecarbonitrile's production and use in organic synthesis(1) may result in its release to the environment through various waste streams(SRC).
- 生态毒性值： USDA APHIS Chemical Effects: collection=usda_chemeffect&query_type=synonym&query='^100-54-9$'
- 水/土壤挥发率： The Henry's Law constant for 3-pyridinecarbonitrile is 2.74X10-7 atm-cu m/mole(1). This Henry's Law constant indicates that 3-pyridinecarbonitrile is not expected to volatilize from water and moist soil surfaces(2). 3-Pyridinecarbonitrile is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.296 mm Hg(3).
- 危害类别和分类： Specific target organ toxicity - Repeated exposure - Category 2 (blood system, testis)
- 环境生物降解性： ANAEROBIC: The maximum pseudo-first-order rate constant and half-life for 3-pyridinecarbonitrile in an anoxic sediment slurry from the estuary of the Tansui River (Guandu, Taipei) were 9.41 per day and 1.7 hrs, respectively(1). 3-Pyridinecarbonitrile was not transformed in the sterile control sediment slurry(1) which suggests that 3-pyridinecarbonitrile may degrade in the environment at least under anaerobic conditions(SRC).
- 土壤吸附/迁移性： The Koc of 3-pyridinecarbonitrile is estimated as 37(SRC), using a measured log Kow of 0.36(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 3-pyridinecarbonitrile is expected to have very high mobility in soil(SRC).
- 个人防护装备 (PPE)： Depending on the extent of possible contact, workers should be provided with personal protective equipment. A charcoal gas mask canister respirator has been found to be effective against a 2% pyridine concentration at 30 l/min for 1 hr. Rubber and plastic gloves should not be relied upon to prevent skin contact because pyridine and many of its derivatives penetrate these materials ... . /Pyridine, homologs, and derivatives/
- 人体暴露可能途径： Occupational exposure to 3-pyridinecarbonitrile may occur through inhalation and dermal contact with this compound at workplaces where 3-pyridinecarbonitrile is produced or used. (SRC)
- 环境生物富集作用： An estimated BCF of 3 was calculated for 3-pyridinecarbonitrile(SRC), using a log Kow of 0.36(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
- 环境非生物降解性： The rate constant for the vapor-phase reaction of 3-pyridinecarbonitrile with photochemically-produced hydroxyl radicals has been estimated as 6.53X10-14 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 246 days at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). 3-Pyridinecarbonitrile is expected to undergo slow hydrolysis in the environment based upon the slow hydrolysis of other aromatic nitriles, eg, benzonitrile(2). 3-Pyridinecarbonitrile is also not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum (>290 nm)(SRC).
- 环境归宿/暴露摘要： 3-吡啶腈的合成和使用于有机合成中可能导致其通过各种废物流释放到环境中。如果释放到空气中，0.296 mm Hg 的蒸气压（在 25 °C）表明 3-吡啶腈仅以蒸气形式存在于环境大气中。气相态的 3-吡啶腈将通过与光化学产生的羟基自由基反应而在大气中被降解；该反应在空气中的半衰期估计为 246 天。如果释放到土壤中，基于估算的 Koc 值为 37，预计 3-吡啶腈具有非常高的迁移性。挥发从湿润土壤表面来说不是重要的命运过程，基于亨利定律常数为 2.74X10^-7 atm-cu m/mole。如果释放到水中，3-吡啶羧...
- 皮肤、眼睛和呼吸道刺激： 吡啶及其衍生物接触皮肤、粘膜和角膜会引起局部刺激。/吡啶及其衍生物/
- EPA临时同行评审毒性值： PPRTV Assessment: PDF Document
上下游信息
上游信息
制造方法：
3-甲基吡啶 (CID:7970)；氨 (CID:222)
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