Aripiprazole是一种人5-HT1A受体激动剂，Ki为4.2 nM。 阿立哌唑的主要成分为 3, 4 二氢-2-(1H) 喹啉酮。 阿立哌唑已被用于研究其对乳腺肿瘤发生的影响，通过逆转录病毒传递受体酪氨酸蛋白激酶 2 或 HRas 原癌基因、gtp 酶或通过转基因表达 Wnt-1（原癌蛋白）介导。也用于研究其对幼年自发性高血压大鼠的行为和神经化学作用。 阿立哌唑已被用于研究阿立哌唑对注意缺陷多动障碍 (ADHD) 模型幼年自发性高血压大鼠 (SHR) 的行为和神经化学的影响。 A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity. Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity. Aripiprazole has been used to study behavioral and neurochemical effects of aripiprazole treatment in juvenile spontaneously hypertensive rats (SHR), a model for attention deficit hyperactivity disorder (ADHD). Aripiprazole has been used to study its effect on mammary tumorigenesis, mediated by retrovirus delivery of receptor tyrosine-protein kinase 2 or HRas proto-oncogene, GTPase or by transgenic expression of Wnt-1 (proto-oncoprotein). It has also been used to study its behavioral and neurochemical effects in juvenile spontaneously hypertensive rats.